The aim of this work was to formulate and evaluate the sumatriptan succinate fast dissolving buccal films used for the treatment of migraine. The design of developing fast dissolving drug delivery systems is to provide patient with more convenient means of drug administration and maximum drug dissolution in oral cavity and to bypass the first metabolism, to increase the convenience and compliance by the pediatric and geriatric patients. In the present investigation, HPMC was used as film forming agent, sodium starch glycolate was used as super disintegrant. Polyethylene glycol was used as plasticizer. Solvent evaporation method was used for the preparation of fast dissolving buccal films. The films were prepared and evaluated for film thickness, folding endurance, dispersion test, drug content and dissolution. Among all the formulations, formulation F1 released the drug up to 98% from the film within 35 seconds of time which exhibits faster absorption and also shows desirable characteristics of the film.
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